Design of Fucoidan Functionalized - Iron Oxide Nanoparticles for Biomedical Applications

Author(s): Khanh Nghia Tran , Phuong Ha-Lien Tran , Toi Van Vo , Thao Truong-Dinh Tran .

Journal Name: Current Drug Delivery

Volume 13 , Issue 5 , 2016

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Abstract:

This research aims to develop an iron oxide nanoparticle drug delivery system utilizing a recent material discovered from ocean, fucoidan. The material has drawn much interest due to many biomedical functions that have been proven for human health. One interesting point herein is that fucoidan is not only a sulfated polysaccharide, a polymer for stabilization of iron oxide nanoparticles, but plays a role of an anticancer agent also. Various approaches were investigated to optimize the high loading efficiency and explain the mechanism of nanoparticle formations. Fucoidan was functionalized on iron oxide nanoparticles by a direct coating or via amine groups. Also, a hydrophobic part of oleic acid was conjugated to the amine groups for a more favorable loading of poorly water-soluble anticancer drugs. This study proposed a novel system and an efficient method to functionalize fucoidan on iron oxide nanoparticle systems which will lead to a facilitation of a double strength treatment of cancer.

Keywords: Curcumin, Fucoidan, Iron oxide nanoparticles, Paclitaxel, Ultrasonication.

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Article Details

VOLUME: 13
ISSUE: 5
Year: 2016
Page: [774 - 783]
Pages: 10
DOI: 10.2174/1567201812666151020100921
Price: $58

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