Novel and Emerging Targeted Therapies of Colorectal Cancer

Author(s): Niklas Finnberg, Prashanth Gokare, Wafik S. El-Deiry.

Journal Name: Current Clinical Pharmacology

Volume 10 , Issue 4 , 2015

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Abstract:

The survival rate of patients with colorectal cancer (CRC) is steadily increasing over the past decade. However, CRC continue to be one of the leading causes of cancer-related fatality in the United States. Current targeted strategies offer limited clinical benefits and the overall survival rate for CRC remains low. Improved understanding of the molecular changes associated with CRC that control growth factor signaling and evasion of cell death allow for the development of improved targeted therapy. This review aims to discuss some of the emerging therapies aimed to target CRC.

Keywords: Clinical, colorectal cancer, DPYD, RAS, targeted therapy, TRAIL.

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Article Details

VOLUME: 10
ISSUE: 4
Year: 2015
Page: [279 - 298]
Pages: 20
DOI: 10.2174/1574884710666151020095911
Price: $58

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