Natural Monophenols as Therapeutics, Antioxidants and Toxins; Electron Transfer, Radicals and Oxidative Stress

Author(s): Peter Kovacic, Ratnasamy Somanathan, Marie-Caline Z. Abadjian.

Journal Name: The Natural Products Journal

Volume 5 , Issue 3 , 2015

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Abstract:

Natural monophenols exhibit various properties including antioxidant, therapeutic action and toxicity. This review is unique in application of a unifying mechanistic theme comprising electron transfer, reactive oxygen species and oxidative stress. Representative phenols are as follows: salicylic acid, guaiacol, eugenol, (S)-tyrosine, vanillin, capsaicin, 6-gingerol, carvacrol, thymol, tocopherol, 5-hydroxytryptamine, psilocin, sesamol, estradiol, cannabinoids, etoposide, morphine and heroin, cresols, and other related phenols, such as platensimycin and polyphenols (vancomycin and tetarimycin A). This approach to mode of action may assist in improved drug design.

Keywords: Antioxidants, electron transfer, monophenols, radicals, therapy, toxicity.

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Article Details

VOLUME: 5
ISSUE: 3
Year: 2015
Page: [142 - 151]
Pages: 10
DOI: 10.2174/221031550503151016153837
Price: $58

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