Benefits of L-Arginine on Cardiovascular System

Author(s): Emina Sudar-Milovanovic, Milan Obradovic, Aleksandra Jovanovic, Bozidarka Zaric, Sonja Zafirovic, Anastasija Panic, Djordje Radak, Esma R. Isenovic.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 16 , Issue 2 , 2016

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Abstract:

The amino acid, L-Arginine (L-Arg) plays an important role in the cardiovascular system. Data from the literature show that L-Arg is the only substrate for the production of nitric oxide (NO), from which L-Arg develops its effects on the cardiovascular system. As a free radical, NO is synthesized in all mammalian cells by L-Arg with the activity of NO synthase (NOS). In states of hypertension, diabetes, hypercholesterolemia and vascular inflammation a disorder occurs in the metabolic pathway of the synthesis of NO from L-Arg which all together bring alterations of blood vessels. Experimental results obtained on animals, as well as clinical studies show that L-Arg has an effect on thrombocytes, on the process of coagulation and on the fibrolytic system. This mini review represents a summary of the latest scientific animal and human studies related to L-Arg and its mechanisms of actions with a focus on the role of L-Arg via NO pathway in cardiovascular disorders. Moreover, here we present data from recent animal and clinical studies suggesting that L-Arg could be one of the possible therapeutic molecules for improving the treatment of different cardiovascular disorders.

Keywords: Amino acid, Arginase, cardiovascular system, cardiovascular disorders, L-Arg, NO, NOS.

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Article Details

VOLUME: 16
ISSUE: 2
Year: 2016
Page: [94 - 103]
Pages: 10
DOI: 10.2174/1389557515666151016125826

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