Mitochondria play important roles as energetic centers. Mutations in mitochondrial DNA
(mtDNA) were found in several diseases, including cancers. Studies on cytoplasmic hybrids (cybrids)
confirm that directed mutation introduced into mtDNA could be a reason for cancer induction.
Mitochondria could also be a factor linking cancer transformation and progression. The importance of
mitochondria in cancer also confirms their involvement in the resistance to treatment. Resistance to
treatment of cancer cells can frequently be a reason for glycolysis acceleration. It could be explained
by cancer cells’ high proliferation index and high energy request. The involvement of mitochondria in
metabolic disturbances of several metabolic diseases, including cancers, was reported. These data confirm that cancer
induction, as well as cancer progression, could have metabolic roots. The aberrant products observed in prostate cells
involved in the Krebs cycle could promote cancer progression. These multiple relationships between alterations on a
genetic level translated into disturbances in cellular metabolism and their potential relation with epigenetic control of gene
expression make cancerogenesis more complicated and prognoses’ success in studies on cancer etiology more distant in
Keywords: Anticancer drugs, cancer cell metabolic alterations, cancer progression, carcinogenesis, mtDNA alterations.
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