Metabolic Alterations in Renal and Prostate Cancer

Author(s): Chiara Ciccarese, Matteo Santoni, Francesco Massari, Alessandra Modena, Francesco Piva, Alessandro Conti, Roberta Mazzucchelli, Liang Cheng, Antonio Lopez-Beltran, Marina Scarpelli, Giampaolo Tortora, Rodolfo Montironi.

Journal Name: Current Drug Metabolism

Volume 17 , Issue 2 , 2016


Abstract:

Background: Cancer metabolism is emerging as a promising research area in genitourinary tumors. Both renal cell carcinoma (RCC) and prostate cancer (PCa) cells exhibit marked alterations of their metabolism. These changes include increased aerobic glycolysis (the Warburg effect), increased protein and DNA synthesis and de novo fatty acid (FA) synthesis.

Objective: Understanding the molecular mechanisms underlying such alterations will represent a major step forward in cancer research. Indeed, reprogramming cancer cell energy metabolism represents a promising hallmark of cancer and may pave the way for novel personalized approaches.

Method: PubMed databases were searched for articles published about cancer metabolism in genitourinary tumors. Results and Conclusion: This review is focused on the metabolic alterations that occur in RCC and PCa and describes the mechanisms underlying such metabolic changes.

Keywords: Cancer metabolism, glycolysis, lipogenesis, prostate cancer, renal cell carcinoma, warburg effect.

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Article Details

VOLUME: 17
ISSUE: 2
Year: 2016
Page: [150 - 155]
Pages: 6
DOI: 10.2174/1389200216666151015112356
Price: $58

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