Biologic Therapy in Inflammatory and Immunomediated Skin Diseases: Safety Profile

Author(s): Giulia Ganzetti, Anna Campanati, E. Molinelli, A. Offidani.

Journal Name: Current Drug Safety

Volume 11 , Issue 1 , 2016

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Abstract:

Biologic treatments have modified the therapeutic armamentarium in the treatment of many dermatological and non- dermatological diseases and data on literature have widely focused on the efficacy and safety of TNF-alpha inhibitors in psoriasis.

Although the etiopathogenesis has not completely elucidated, inflammation appears the lait motif unifying the immune-pathogenesis of diverse skin disease, as atopic dermatitis, alopecia areata and hidradenitis suppurativa.

Actually, data on the off-label use of biologics in cutaneous immune-mediated inflammatory diseases are scarce and restricted to anecdotal cases and case series.

The present review aims to evidence the major off- label use of TNF-alpha inhibitors in dermatology.

Keywords: Inflammation, immuno-mediated disease, anti-TNF-alpha, off-label use.

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Article Details

VOLUME: 11
ISSUE: 1
Year: 2016
Page: [12 - 21]
Pages: 10
DOI: 10.2174/1574886310666151014121732

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