Background: Organic reactions accelerated by microwave irradiation is an area of great
interest in recent times. Several organic reactions are usually slow under normal or thermal conditions,
however, use of microwave irradiation reduces the reaction time significantly. Multi component reactions
(MCRs) are of interest due to nature of complex products formed in a one pot reaction.
Methods: The reaction (MCR) is accelerated by montmorillonite K10 catalyst under microwave conditions.
Results: Microwave assisted ‘montmorillonite K10’ catalysed synthesis of novel 1-(2,7-dimethyl-5-phenyl-5H-thiazolo[3,2-a]pyrimidin-6-yl)ethanone based fused heterocyclic compounds of medicinal
interest is reported in this communication. The reaction is carried out by taking an aldehyde, amine and a 1,3 ketone
(1:1:1), alongwith montmorillonite K10 (catalytic) in solvent free condition in an ecofriendly manner under microwave irradiation
for about 5 mins followed by chromatography. All new compounds obtained in excellent yields are well characterized
by 1HNMR, IR, Mass etc.
Conclusion: A very efficient, MCR involving montmorillonite K10 catalyst and microwave irradiation is reported in this
communication for the synthesis of several novel 1-(2,7-dimethyl-5-phenyl-5H-thiazolo[3,2-a]pyrimidin-6-yl)ethanone
derivatives of medicinal interest.