The Correlated Factors of Serum CA19-9 Levels in Diabetic Patients

Author(s): Qiuming Jiang, Lei Lei, Xiyang Zhang, Jennifer Pressley, Yuanjie Mao.

Journal Name: Current Diabetes Reviews

Volume 13 , Issue 1 , 2017

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Abstract:

Background: Serum CA19-9 level is a sensitive marker for pancreatic tissue damage; however, its correlation factors are still unclear in diabetic patients. This study was aimed to investigate the correlation factors of serum CA 19-9 levels in these patients.

Methods and Results: Based on their serum CA19-9 levels, 412 diabetic patients (57 type 1 and 355 type 2) were divided into the negative group (432 cases, CA19-9 < 37 U /ml) and the positive group (31 cases, CA19-9 ≥ 37 U /ml). The two groups were compared with age, sex, duration of diabetic history, hemoglobin A1c, blood lipid, fasting C-peptide level, and area under the curve C-peptide. The difference was significant between 2 groups in age, hemoglobin A1c, total cholesterol, highdensity lipoprotein cholesterol, fasting C-peptide level, and area under the curve C-peptide (P < 0.05). A multivariate linear regression model found that the type of diabetes, hemoglobin A1c, area under the curve C-peptide, and high-density lipoprotein cholesterol are the independent contributors to CA19-9 levels.

Conclusion: The results indicated that CA19-9 levels in patients with diabetes mellitus were related to not only age and sex but also diabetic type, hemoglobin A1c, lipid metabolism, and pancreatic beta cell function.

Keywords: CA19-9, diabetes mellitus, Hemoglobin A1c, C-peptide, total cholesterol, high-density lipoprotein cholesterol.

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Article Details

VOLUME: 13
ISSUE: 1
Year: 2017
Page: [47 - 49]
Pages: 3
DOI: 10.2174/1573399812666151012115546
Price: $58

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