Background: Serum CA19-9 level is a sensitive marker for pancreatic tissue damage;
however, its correlation factors are still unclear in diabetic patients. This study was aimed to investigate
the correlation factors of serum CA 19-9 levels in these patients.
Methods and Results: Based on their serum CA19-9 levels, 412 diabetic patients (57 type 1 and 355
type 2) were divided into the negative group (432 cases, CA19-9 < 37 U /ml) and the positive group
(31 cases, CA19-9 ≥ 37 U /ml). The two groups were compared with age, sex, duration of diabetic
history, hemoglobin A1c, blood lipid, fasting C-peptide level, and area under the curve C-peptide.
The difference was significant between 2 groups in age, hemoglobin A1c, total cholesterol, highdensity
lipoprotein cholesterol, fasting C-peptide level, and area under the curve C-peptide (P <
0.05). A multivariate linear regression model found that the type of diabetes, hemoglobin A1c, area
under the curve C-peptide, and high-density lipoprotein cholesterol are the independent contributors
to CA19-9 levels.
Conclusion: The results indicated that CA19-9 levels in patients with diabetes mellitus were related
to not only age and sex but also diabetic type, hemoglobin A1c, lipid metabolism, and pancreatic
beta cell function.