Cohesive powders are problematic in the manufacturing of pharmaceutical solid dosage forms because
they exhibit poor flowability, fluidization and aerosolization. These undesirable bulk properties of cohesive powders
represent a fundamental challenge in the design of efficient pharmaceutical manufacturing processes. Recently,
mechanical dry coating has attracted increasing attention as it can improve the bulk properties of cohesive
powders in a cheaper, simpler, safer and more environment-friendly way than the existing solvent-based counterparts.
In this review, mechanical dry coating techniques are outlined and their potential applications in formulation
and manufacturing of pharmaceutical solid dosage forms are discussed. Reported data from the literature have
shown that mechanical dry coating holds promise for the design of superior pharmaceutical solid formulations or
manufacturing processes by engineering the interfaces of cohesive powders in an efficient and economical way.
Keywords: Mechanical dry coating, flowability, fluidization, aerosolization, tableting, dissolution, coating quality, computational modeling.
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