Particle Engineering Via Mechanical Dry Coating in the Design of Pharmaceutical Solid Dosage Forms

Author(s): Li Qu , David A.V. Morton , Qi (Tony) Zhou .

Journal Name: Current Pharmaceutical Design

Volume 21 , Issue 40 , 2015

Abstract:

Cohesive powders are problematic in the manufacturing of pharmaceutical solid dosage forms because they exhibit poor flowability, fluidization and aerosolization. These undesirable bulk properties of cohesive powders represent a fundamental challenge in the design of efficient pharmaceutical manufacturing processes. Recently, mechanical dry coating has attracted increasing attention as it can improve the bulk properties of cohesive powders in a cheaper, simpler, safer and more environment-friendly way than the existing solvent-based counterparts. In this review, mechanical dry coating techniques are outlined and their potential applications in formulation and manufacturing of pharmaceutical solid dosage forms are discussed. Reported data from the literature have shown that mechanical dry coating holds promise for the design of superior pharmaceutical solid formulations or manufacturing processes by engineering the interfaces of cohesive powders in an efficient and economical way.

Keywords: Mechanical dry coating, flowability, fluidization, aerosolization, tableting, dissolution, coating quality, computational modeling.

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Article Details

VOLUME: 21
ISSUE: 40
Year: 2015
Page: [5802 - 5814]
Pages: 13
DOI: 10.2174/1381612821666151008151001
Price: $58

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