Metal-Catalyzed Cross-Coupling of Terminal Alkynes with Different Carbene Precursors

Author(s): Jiuwei Che , Dong Xing , Wenhao Hu .

Journal Name: Current Organic Chemistry

Volume 20 , Issue 1 , 2016

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Abstract:

Metal carbene-involved C-H insertion reaction is among the most useful and efficient method for the construction of C-C bonds. While C(sp3)-H insertion and C(sp2)-H insertion have been intensively studied during the past several decades, C(sp)-H insertion of terminal alkynes with metal carbenes has only received great attention from the synthetic community recently. This cross-coupling reaction between terminal alkynes with different metal carbene precursors offers a versatile strategy for the synthesis of different types of alkynes or allenes, which are very useful synthetic intermediates in organic synthesis. This type of cross-coupling reaction, in which a migratory insertion step of alkynylsubstituted metal carbene species is generally involved, also offers new opportunities for the development of related cascade or multicomponent reactions.

Keywords: Terminal alkyne, cross-coupling, metal carbene, migratory insertion, diazo compound, N-Tosylhydrazone, allene, C(sp)-H insertion.

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Article Details

VOLUME: 20
ISSUE: 1
Year: 2016
Page: [41 - 60]
Pages: 20
DOI: 10.2174/1385272819666151008014517

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