Sesquiterpenoids, consist of 15 carbons backbone, may play a highly significant role in
natural products. There are various types of the sesquiterpenoids due to different spatial configurations
via modification and rearrangement. Sesquiterpenoids exhibit various biological activities:
anti-tumor, anti-viral, anti-microbial, anti-inflammatory and so on. The study on sesquiterpenes
may receive more and more attentions, and will increase the chance to discover bio-active drug
leads with medicinal potential. The present paper reviews the latest progress in the structural
diversity and the biological activity of the new sesquiterpenes isolated from natural resource in
recent years. Overall, 337 compounds, and 201 references are presented.