Anticancer Activity of Organogallium(III) Complexes in Colon Cancer Cells

Author(s): Milena R. Kaluđerović, Marija Mojić, Santiago Gómez-Ruiz, Sanja Mijatović, Danijela Maksimović-Ivanić.

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 16 , Issue 3 , 2016

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Abstract:

In vitro antitumor activity of various organogallium(III) complexes (1–8) has been tested against CT26CL25, HCT116, SW480 colon cancer cell lines. CV and MTT assays were used to assess on the antiproliferative effect of investigated organogallium(III) complexes. From the investigated complexes, the most active was found to be tetranuclear compound 8 against CT26CL25 cells. Flow cytometric analysis of the CT26CL25 cells upon the treatment with 8 was performed in order to determine the role of apoptosis, caspase activation, autophagy and proliferation rate on the cell death caused with this compound. Results indicate cytotoxic potential of the tetranuclear complex 8 by inducing caspase independent apoptosis and blocking most of the cells before first division.

Keywords: Apoptosis, autophagy, cell division, cisplatin, cytotoxic activity, organogallium(III) complexes.

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Article Details

VOLUME: 16
ISSUE: 3
Year: 2016
Page: [359 - 364]
Pages: 6
DOI: 10.2174/1871520615666151007160319
Price: $58

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