In vitro antitumor activity of various organogallium(III) complexes (1–8) has been tested against
CT26CL25, HCT116, SW480 colon cancer cell lines. CV and MTT assays were used to assess on the
antiproliferative effect of investigated organogallium(III) complexes. From the investigated complexes, the most
active was found to be tetranuclear compound 8 against CT26CL25 cells. Flow cytometric analysis of the
CT26CL25 cells upon the treatment with 8 was performed in order to determine the role of apoptosis, caspase
activation, autophagy and proliferation rate on the cell death caused with this compound. Results indicate cytotoxic
potential of the tetranuclear complex 8 by inducing caspase independent apoptosis and blocking most of the cells before first division.
Keywords: Apoptosis, autophagy, cell division, cisplatin, cytotoxic activity, organogallium(III) complexes.
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