There are rapidly replicating human data suggesting the therapeutic and neurorestorative
role of repetitive transcranial magnetic stimulation (rTMS) in clinical depression. However there are
only limited experimental studies in the literature and the neurobiological mechanisms of the technique
are still unclear. Studies have suggested that modulating of either excitatory or inhibitory neural
circuitry may be responsible for the mechanism of action of rTMS while it is still unclear whether
rTMS exerts a neuroprotective effect. In the light of these findings, we aimed to review the neuroprotective
effect of rTMS in animal models of depression. We have shown that rTMS may exert significant
neuroprotective effect through acting on the oxidative injury, stress hormones, dopamine and serotonin levels, Brain
Derived Neurotrophic Factor expression, neuroinflamation and hippocampal cell proliferation.
Keywords: Transcranial magnetic stimulation, neuroprotection, depression.
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