Microwave Assisted Synthesis and Antifungal Activity of Some Novel Hydrazones Containing Pyridine Moiety

Author(s): Li-Jing Min, Yan-Xia Shi, Ming-Yan Yang, Zhi-Wen Zhai, Jian-Quan Weng, Cheng-Xia Tan, Xing-Hai Liu, Bao-Ju Li, Yong-Gang Zhang.

Journal Name: Letters in Drug Design & Discovery

Volume 13 , Issue 4 , 2016

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Abstract:

A series of novel hydrazone derivatives containing pyridine moiety were designed and synthesized from 2,3-dichloro-5-(trifluoromethyl)pyridine as starting materials under microwave irradiation, and their structures were characterized by 1H NMR, MS and elemental analysis. The biological activity of title compounds was determined. The results indicated that some of title compounds exhibited good antifungal activity.

Keywords: Hydrazone, pyridine, microwave assistant synthesis, antifungal activity.

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Article Details

VOLUME: 13
ISSUE: 4
Year: 2016
Page: [324 - 328]
Pages: 5
DOI: 10.2174/1570180812666151003002140
Price: $58

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