Monoamine Oxidase Inhibitory Action of Chalcones: A Mini Review

Author(s): Bijo Mathew, Abitha Haridas, Jerad Suresh, Githa E. Mathew, Gülberk Uçar, Venkatesan Jayaprakash.

Journal Name: Central Nervous System Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Central Nervous System Agents)

Volume 16 , Issue 2 , 2016

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Abstract:

Introduction: Chalcones are one of the major classes of naturally occurring compounds and have a vast significance in medicinal chemistry, presenting with a wide scope of pharmacological actions.

Discussion: The present review focused our attention onto the monoamine oxidase inhibitory activity of natural and synthetic chalcones. The review also emphasises the structure-activity relationship studies and molecular recognition of chalcones towards MAO-A and B inhibition.

Conclusion: Many of the studies clearly revealed that most of the chalcones showed selective, reversible and potent MAO-B inhibition compared to MAO-A. Recent studies also showed that heteroaryl-based chalcones are potent MAO-A inhibitors.

Keywords: Alzheimer's disease, Chalcones, Depression, MAO-A, MAO-B.

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Article Details

VOLUME: 16
ISSUE: 2
Year: 2016
Page: [120 - 136]
Pages: 17
DOI: 10.2174/1871524915666151002124443
Price: $58

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