Abstract
Corynantheine alkaloids with a tetracyclic indole[2,3-a]-quinolizidine motif are an important issue in academia and in the life science industries due to their broad bioactivity profile. In particular, the main biological effects described for indoloquinolizidines include analgesic, anti-inflammatory, antihypertensive, and antiarrhythmic activities, as well as inhibition of multiple ion channels, affinity for opioid receptors, and activity against Leishmania. For that reason, in the last decades, numerous efforts have been invested in the development of novel synthetic strategies to obtain the indole[2,3-a]-quinolizidine system. This review focuses on the synthetic methodologies developed to target the most important alkaloids of this family, and highlights the potential use of these alkaloids or analogs to treat several diseases, ranging from cancer to neurodegenerative disorders.
Keywords: Indoloquinolizidines, corynantheine alkaloids, indole alkaloids, natural products, bioactivity.
Current Pharmaceutical Design
Title:Indolo[2,3-a]quinolizidines and Derivatives: Bioactivity and Asymmetric Synthesis
Volume: 21 Issue: 38
Author(s): Maria Perez, Margarida Espadinha and Maria M. M. Santos
Affiliation:
Keywords: Indoloquinolizidines, corynantheine alkaloids, indole alkaloids, natural products, bioactivity.
Abstract: Corynantheine alkaloids with a tetracyclic indole[2,3-a]-quinolizidine motif are an important issue in academia and in the life science industries due to their broad bioactivity profile. In particular, the main biological effects described for indoloquinolizidines include analgesic, anti-inflammatory, antihypertensive, and antiarrhythmic activities, as well as inhibition of multiple ion channels, affinity for opioid receptors, and activity against Leishmania. For that reason, in the last decades, numerous efforts have been invested in the development of novel synthetic strategies to obtain the indole[2,3-a]-quinolizidine system. This review focuses on the synthetic methodologies developed to target the most important alkaloids of this family, and highlights the potential use of these alkaloids or analogs to treat several diseases, ranging from cancer to neurodegenerative disorders.
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Cite this article as:
Perez Maria, Espadinha Margarida and Santos M. M. Maria, Indolo[2,3-a]quinolizidines and Derivatives: Bioactivity and Asymmetric Synthesis, Current Pharmaceutical Design 2015; 21 (38) . https://dx.doi.org/10.2174/1381612821666151002112934
DOI https://dx.doi.org/10.2174/1381612821666151002112934 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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