Corynantheine alkaloids with a tetracyclic indole[2,3-a]-quinolizidine motif are an important issue in academia
and in the life science industries due to their broad bioactivity profile. In particular, the main biological effects
described for indoloquinolizidines include analgesic, anti-inflammatory, antihypertensive, and antiarrhythmic
activities, as well as inhibition of multiple ion channels, affinity for opioid receptors, and activity against Leishmania.
For that reason, in the last decades, numerous efforts have been invested in the development of novel synthetic
strategies to obtain the indole[2,3-a]-quinolizidine system. This review focuses on the synthetic methodologies developed
to target the most important alkaloids of this family, and highlights the potential use of these alkaloids or
analogs to treat several diseases, ranging from cancer to neurodegenerative disorders.