Arene ruthenium(II) Complexes: The Promising Chemotherapeutic Agent in Inhibiting the Proliferation, Migration and Invasion

Author(s): Kangdi Zheng, Qiong Wu, Yang Ding, Wenjie Mei.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 16 , Issue 10 , 2016

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Abstract:

Arene ruthenium(II) complexes have been widely investigated as one of the most promising candidates in chemotherapy because of their low toxicity and high inhibiting activity against the proliferation, invasion, migration, and angiogenesis of various tumors in vitro and in vivo. This review highlights the recent developments in different chemical types of arene Ru(II) complexes, as well as their biological activity and underlying mechanisms. The sustained efforts in this aspect of arene Ru(II) complexes would be essential in developing novel anti-tumor agents in the near future.

Keywords: Apoptosis, Arene ruthenium(II) complexes, cell cycle arrest, invadopodia, migration, invasion.

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Article Details

VOLUME: 16
ISSUE: 10
Year: 2016
Page: [796 - 803]
Pages: 8
DOI: 10.2174/1389557515666151001142159
Price: $65

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