Gastrin-Releasing Peptide Receptor Targeting in Cancer Treatment: Emerging Signaling Networks and Therapeutic Applications

Author(s): Mikko O. Laukkanen, Maria Domenica Castellone.

Journal Name: Current Drug Targets

Volume 17 , Issue 5 , 2016

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Abstract:

Growth factors of the bombesin/gastrin releasing peptide (BN/GRP) family play a critical role in proliferation and progression of malignancies. Inhibitors targeting GRP signalling have been developed and tested as anticancer compounds showing promising preclinical and early phase clinical results. In this review, we will discuss the molecular signaling, expression and the functional role of BN/GRP-GRPR in different cancer models and will focus on the available strategies to target BN/GRP-GRPR in cancer treatment as well as in tumour diagnosis and follow up.

Keywords: Cancer, neuropeptide, signaling transduction, drug targets, clinical trial.

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Article Details

VOLUME: 17
ISSUE: 5
Year: 2016
Page: [508 - 514]
Pages: 7
DOI: 10.2174/1389450116666151001112130
Price: $58

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