Nanosponge Carriers- An Archetype Swing in Cancer Therapy: A Comprehensive Review

Author(s): Riyaz Ali M. Osmani, Umme Hani, Rohit R. Bhosale, Parthasarathi K. Kulkarni, Seetharaman Shanmuganathan.

Journal Name: Current Drug Targets

Volume 18 , Issue 1 , 2017

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Abstract:

Nanotechnology and nanomedicines are emerging research meadows; which chiefly focuses on creating and manipulating materials at a nanometer level for the betterment in imaging, diagnosis and treatment of a range of diseases together with cancer. Cyclodextrin-based nanosponges, anticipated as a new-fangled nanosized delivery system, are ground-breaking hyper-crosslinked cyclodextrin polymers nanostructured within a three-dimensional network. Nanosponges based systems hold the potential of elevating the solubility, absorption, penetration, bioavailability, in vivo stability, targeted as well as sustained delivery, and therapeutic efficiency of numerous anticancer agents. The extension of nanosponges based drug delivery systems is an exhilarating and demanding research pasture, predominantly to overcome aforementioned problems allied to existing anticancer formulations and for the further progressions in cancer therapies. Nanosponges in cancer therapy, particularly cyclodextrin based nanosponges are brought up in this review. By quoting diverse attempts made in pertinent direction, efforts have been made to exemplify the characteristics, suitability and versatility of cyclodextrin based nanosponges for their promising applications in cancer treatment.

Keywords: Bioavailability, cancer, cyclodextrin, cytotoxicity, nanosponges, targeted delivery.

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Article Details

VOLUME: 18
ISSUE: 1
Year: 2017
Page: [108 - 118]
Pages: 11
DOI: 10.2174/1389450116666151001105449
Price: $58

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