Calcium Handling and Arrhythmogenesis

Author(s): Georgios C. Bompotis , Loukas K. Pappas , Christos Angelidis , Charalampos Kossyvakis , Georgios Giannopoulos , Spyridon Deftereos .

Journal Name: Medicinal Chemistry

Volume 12 , Issue 2 , 2016

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Abstract:

Intracellular calcium homeostasis plays a fundamental role in the electric and mechanical function of the heart by modulating action potential pattern and duration, by linking cell membrane depolarization to myocardial contraction and by regulating cardiac automaticity. Abnormalities of intracellular calcium regulation disrupt the electrophysiological properties of the heart and create an arrhythmogenic milieu, which promotes atrial and ventricular arrhythmogenesis and impairs cardiac automaticity and atrioventricular conduction. In this brief review, we summarize the basic genetic, molecular and electrophysiological mechanisms linking inherited or acquired intracellular Ca2+ dysregulation to arrhythmogenesis.

Keywords: Calcium, arrhythmia, pathophysiology, pathogenesis.

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Article Details

VOLUME: 12
ISSUE: 2
Year: 2016
Page: [170 - 176]
Pages: 7
DOI: 10.2174/157340641202160209102839
Price: $58

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