Evidence of Stability of Medicines Repackaged in Compliance Aids: A Review
Beverley D. Glass.
Compliance Aids have gained widespread use to assist patients in managing their medicines, with a view to
addressing the issue of adherence. However, although patient outcomes may have been improved through better use of
compliance aids, it has been highlighted that there are limited data on the stability of medicines, when removed from the
original container and repackaged in a compliance aid. Exposure of medicines to heat, light, moisture and air (oxygen)
may impact on both their chemical and physical stability, resulting in the potential for quality of the medicine and thus the
safety for the patient being compromised. It is also uncertain whether the compliance aid can provide the same protection
from these environmental conditions as the manufacturer’s packaging, even though the time frame for repackaging is only
28 days. This paper presents a comprehensive review and detailed discussion of the available literature on the stability
implications of repackaging medicines into compliance aids. The importance of repackaging is thus highlighted by its
ability to impact on therapeutic outcomes for patients.
Keywords: Dose Administration Aids, quality, repackaging, safety, stability, storage.
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