Furazano[3,4-b]quinoxaline 1-oxides indicate significant chemical reactivity and release
NO fragments in their electron impact mass spectra. A series of fused furazan N-oxide derivatives
were synthesized and tested in vitro as potential NO releasing agents in the presence of L- cysteine
used as a thiol cofactor. The synthesized compounds were determined using cysteine as cofactor and
Griess reagent. The yield in nitrite for each compound was expressed as % NO2-
4c showed the higher NO releasing ability among the tested furazan N-oxide derivatives. A new
class of NO-donors, Furazano[3,4-b]quinoxaline 1-Oxides hybrids was developed by joining NOdonor
furoxan moiety to substituted quinoxaline 1-Oxides. It seems that lipophilicity and stereochemistry of the X substitution
influences the NO donating behavior.
Keywords: Nitric oxide, NO donors, furazano[3, 4-b]quinoxaline 1-Oxides, griess.
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