In vitro Study of Furazano[3,4-b]quinoxaline 1-Oxides as Potential ΝΟ Releasing Agents

Author(s): Kosmas I. Stoitsis, Petros Gkizis, Emmanouella Basgiouraki, John K. Gallos, Dimitra Hadjipavlou-Litina.

Journal Name: Letters in Drug Design & Discovery

Volume 13 , Issue 5 , 2016

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Abstract:

Furazano[3,4-b]quinoxaline 1-oxides indicate significant chemical reactivity and release NO fragments in their electron impact mass spectra. A series of fused furazan N-oxide derivatives were synthesized and tested in vitro as potential NO releasing agents in the presence of L- cysteine used as a thiol cofactor. The synthesized compounds were determined using cysteine as cofactor and Griess reagent. The yield in nitrite for each compound was expressed as % NO2-  (mol/mol). Compound 4c showed the higher NO releasing ability among the tested furazan N-oxide derivatives. A new class of NO-donors, Furazano[3,4-b]quinoxaline 1-Oxides hybrids was developed by joining NOdonor furoxan moiety to substituted quinoxaline 1-Oxides. It seems that lipophilicity and stereochemistry of the X substitution influences the NO donating behavior.

Keywords: Nitric oxide, NO donors, furazano[3, 4-b]quinoxaline 1-Oxides, griess.

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Article Details

VOLUME: 13
ISSUE: 5
Year: 2016
Page: [418 - 421]
Pages: 4
DOI: 10.2174/1570180812666150923235828
Price: $58

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