Cervical cancer has a major impact on the lives of Indian women with an estimated 122, 844 new cases of cervical
cancer in the year 2012. About 80% of these cases present in a locally advanced stage leading to high morbidity and
mortality. Because of lack of public awareness and infrastructure for screening and early detection in developing countries,
this late presentation is likely to continue in the coming years. Radiation therapy has been the treatment of choice for
patients with locally advanced cancer cervix. Many clinical trials and meta-analyses have shown a significant improvement
in overall and progression-free survival with decreased local and distant recurrences with the use of concurrent chemotherapy
with radiation. Most of these trials have been done in women from developed countries where the patient and
disease profile are entirely different from ours. Recently, few trials from India have also shown promising results in locally
advanced cancer cervix with concurrent chemoradiotherapy but toxicities remain a major concern. Further exploration
is required for the use of concurrent chemo radiation prior to incorporating it into routine clinical practice.
Keywords: Cervical cancer, chemotherapy, toxicity, radiation.
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