Context: Vaginal cancer is a rare gynecologic cancer with very little documentation.
Objective: Literature search to have useful information for the management of vaginal cancer and share.
Material Methods: We have searched the PUBMED database, Google search engine and other database. A total of 26 references
were taken into account.
Comments: Once spread from primary other cancers or vulva is ruled out, vaginal cancer is designated to be primary in
origin. It was revealed that majority of vaginal cancers reported are squamous cell carcinomas. The most common risk
factors implicated are Human Papiloma Virus, age. Most common presenting symptoms were abnormal vaginal bleeding,.
Diagnosis requires pathological confirmation. Management depends on staging work-up. Vaginal cancer is staged by
FIGO system of staging and TNM staging. There are many prognostic factors influencing the choice of treatment. Lymph
node metastasis is one of the important prognostic factors, others to mention are histology, size, age. In a recent SEER
analysis of over 2000 patients, the5 year disease specific survival was 84% for stage 1, 75% for stage II and 57% for advanced
tumors. Early carcinomas are generally treated with either surgery or radiation therapy. Advanced cancers are
treated with radiation therapy with simultaneous administration of combined chemotherapy. Preventive strategies include
safe sex and HPV vaccination.
Conclusion: Primary vaginal cancer is a rare entity, if there is no history of cancer cervix or vulva in past or absence of
cervical squamous cell carcinoma or vulvar carcinoma within 5 years is usually considered as primary vaginal cancer.
Though early stage vaginal cancers have better outcome treated with surgery or radiotherapy or surgery followed by radiotherapy,
radiotherapy alone is preferred mode of treatment in vaginal cancers.