Protein homodimers pose some intriguing questions about the relation between structure
and stability. We approached the problem by means of a topological methodology based on protein
contact networks. We correlated local interface descriptors with structure and energy global properties
of the systems under analysis. We demonstrated that the graph energy, formerly applied to the analysis
of unconjugated hydrocarbons structures, is the bridge between the topological and energetic description
of protein complexes. This is a first step for the generation of a “protein structural formula”, analogous to the molecular
graphs in organic chemistry.
Keywords: Homodimers, Protein Contact Network, Complex Networks.
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