Abstract
A novel series of iodo-chrysin derivatives with resorcinol as raw materials were synthesized according to Baker-Venkataraman reaction and their inhibitory activities in vitro against thyroid cancer cell lines (SW-579 and TT) were evaluated by the standard methyl thiazole tetrazolium (MTT) method. Biological test results showed that these derivatives possessed stronger anti-thyroid cancer activities than 5-FU. Compound 21 showed the strongest activity against SW-579 cell lines with IC50 value of 3.4μM and compound 10 showed the strongest activity against TT cell lines with IC50 value of 6.2μM, it was better than 5-FU (59.3μΜ, 18.4μM respectively).
Keywords: Anti-thyroid cancer, activities, Baker-Venkataraman reaction, flavonoids, iodo-chrysin derivatives, MTT method.
Medicinal Chemistry
Title:Synthesis and Anti-thyroid Cancer Effect of Iodo-chrysin Derivatives
Volume: 12 Issue: 5
Author(s): Yun Wei, Qutong Zheng, Guotao Tang, Chen Song, Guan Wang, Yinxiang Zhang, Yan Xiao, Xianliang Zeng, Zongbao Wang, Jichang Xiao and Xing Zheng
Affiliation:
Keywords: Anti-thyroid cancer, activities, Baker-Venkataraman reaction, flavonoids, iodo-chrysin derivatives, MTT method.
Abstract: A novel series of iodo-chrysin derivatives with resorcinol as raw materials were synthesized according to Baker-Venkataraman reaction and their inhibitory activities in vitro against thyroid cancer cell lines (SW-579 and TT) were evaluated by the standard methyl thiazole tetrazolium (MTT) method. Biological test results showed that these derivatives possessed stronger anti-thyroid cancer activities than 5-FU. Compound 21 showed the strongest activity against SW-579 cell lines with IC50 value of 3.4μM and compound 10 showed the strongest activity against TT cell lines with IC50 value of 6.2μM, it was better than 5-FU (59.3μΜ, 18.4μM respectively).
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Cite this article as:
Wei Yun, Zheng Qutong, Tang Guotao, Song Chen, Wang Guan, Zhang Yinxiang, Xiao Yan, Zeng Xianliang, Wang Zongbao, Xiao Jichang and Zheng Xing, Synthesis and Anti-thyroid Cancer Effect of Iodo-chrysin Derivatives, Medicinal Chemistry 2016; 12 (5) . https://dx.doi.org/10.2174/1573406411666150921111220
DOI https://dx.doi.org/10.2174/1573406411666150921111220 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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