Synthesis and Anti-thyroid Cancer Effect of Iodo-chrysin Derivatives

Author(s): Yun Wei, Qutong Zheng, Guotao Tang, Chen Song, Guan Wang, Yinxiang Zhang, Yan Xiao, Xianliang Zeng, Zongbao Wang, Jichang Xiao, Xing Zheng.

Journal Name: Medicinal Chemistry

Volume 12 , Issue 5 , 2016

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Abstract:

A novel series of iodo-chrysin derivatives with resorcinol as raw materials were synthesized according to Baker-Venkataraman reaction and their inhibitory activities in vitro against thyroid cancer cell lines (SW-579 and TT) were evaluated by the standard methyl thiazole tetrazolium (MTT) method. Biological test results showed that these derivatives possessed stronger anti-thyroid cancer activities than 5-FU. Compound 21 showed the strongest activity against SW-579 cell lines with IC50 value of 3.4μM and compound 10 showed the strongest activity against TT cell lines with IC50 value of 6.2μM, it was better than 5-FU (59.3μΜ, 18.4μM respectively).

Keywords: Anti-thyroid cancer, activities, Baker-Venkataraman reaction, flavonoids, iodo-chrysin derivatives, MTT method.

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Article Details

VOLUME: 12
ISSUE: 5
Year: 2016
Page: [441 - 447]
Pages: 7
DOI: 10.2174/1573406411666150921111220
Price: $58

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