Clinical Assessment of Cognitive Decline in Adults with Down Syndrome

Author(s): Marwan Sabbagh, Jamie Edgin.

Journal Name: Current Alzheimer Research

Volume 13 , Issue 1 , 2016

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Abstract:

Down syndrome is an intellectual disability requiring periodic monitoring of cognition given the near universal presence of Alzheimer’s Disease related neuropathology and high rates of dementia in middle adulthood. We review current approaches to detecting decline in this population, including informant-based measures, dementia screening tools, and neuroimaging techniques. The challenges for detecting decline in this group are discussed, including the need to take into account premorbid cognitive function as well as medical comorbidity.

Keywords: Alzheimer’s disease, assessment, decline, dementia, down syndrome, neuropsychological, sleep.

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Article Details

VOLUME: 13
ISSUE: 1
Year: 2016
Page: [30 - 34]
Pages: 5
DOI: 10.2174/1567205012666150921095724

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