Background: The side effects of psychotropic drugs are commonly encountered
in clinical practice. Sexual side effects of psychotropic drugs may affect compliance to the
treatment if not properly treated. Different classes of psychotropic drugs are known to cause
clinically significant sexual dysfunction.
Objective: In this review, authors have attempted to briefly describe the common side
effects of psychotropic agents and their management in day to day clinical practice.
Method: Appropriate internet search was made using keywords.
Results: Antidepressants like Selective Serotonergic Reuptake Inhibitors (SSRIs) and conventional
antipsychotics are associated with distressing sexual dysfunction due to their effects on neurotransmitters like
dopamine, norepinephrine and serotonin. Some of the antidepressants like bupropion and antipsychotics like
aripiprazole are the safest choice in terms of potential to cause sexual dysfunction.
Conclusion: The management of sexual dysfunction due to psychotropics warrants a sensible approach by
clinicians in their day to day practice. Management of sexual dysfunction may entail simple steps like
curtailing the dose of drug, drug holidays and adding adjuvant drugs at times.