Introduction: Some studies have shown that more than 40% of patients with first
episode psychosis (FEP) are non - adherent and treatment with long - acting antipsychotics
(LAIs) may increase their compliance. However, studies on efficacy of LAIs versus oral
antipsychotics for preventing relapse among schizophrenia patients have produced
Objectives: The aim of the present study is to assess in naturalistic settings if patients with FEP treated with
LAIs have a decreased incidence of readmission compared with patients in treatment with oral antipsychotics
over 6 months follow - up.
Methods: 188 FEP patients had been consecutively admitted to Hospital del Mar since January 2008 to
September 2014. Psychometric assessment included: sociodemographic data, duration of untreated psychosis
(DUP), diagnosis, substance use and clinical data at baseline. At 6 - months follow - up, antipsychotic
treatment and number of admissions and emergencies over 6 months were also recorded. We investigated
whether group treatments differ in readmission rates, attendance rates at emergencies services emergencies.
Results: We found a significant decreased incidence of readmission (p=0,000) and a lower number of
emergencies (p=0,017) in the group of FEP patients treated with LAIs versus the group treated with oral
Conclusion: In this naturalistic study, treatment with LAIs is associated with a reduced readmission rate and a
lower number of emergencies in patients with FEP. These findings are in agreement with the results of other
studies showing a significant reduced relapse rate and lowest risk of re - hospitalization in FEP patients
treated with LAIs.