Title:Does Glucagon-like Peptide-1 Ameliorate Oxidative Stress in Diabetes? Evidence Based on Experimental and Clinical Studies
VOLUME: 12 ISSUE: 4
Author(s):Karen Ekkelund Petersen, Günaj Rakipovski, Kirsten Raun and Jens Lykkesfeldt
Affiliation:Faculty of Health and Medical Sciences, University of Copenhagen, DK-1870, Frederiksberg C, Denmark.
Keywords:Glucagon-like peptide-1, oxidative stress, diabetes, diabetic complications.
Abstract:Glucagon-like peptide-1 (GLP-1) has shown to influence the oxidative stress status in a
number of in vitro, in vivo and clinical studies. Well-known effects of GLP-1 including better glycemic
control, decreased food intake, increased insulin release and increased insulin sensitivity may
indirectly contribute to this phenomenon, but glucose-independent effects on ROS level, production
and antioxidant capacity have been suggested to also play a role. The potential ‘antioxidant’ activity
of GLP-1 along with other proposed glucose-independent modes of action related to ameliorating redox
imbalance remains a controversial topic but could hold a therapeutic potential against micro- and
macrovascular diabetic complications. This review discusses the presently available knowledge from
experimental and clinical studies on the effects of GLP-1 on oxidative stress in diabetes and diabetes-related complications.
