A case of 64-year-old man was reported who carried to infection clinic with painful red rash
affecting the right leg and hip for nearly one month. He had previously been treated with oral and intravenous
broad-spectrum antibiotics but had not been recovered. A skin biopsy specimen observed
marked edema of the upper dermis with a diffused inflammatory infiltrate of the upper dermis consisting
mainly of neutrophils. Our patient was diagnosed with Sweet syndrome based on clinical appearance, laboratory investigations
and histological findings. He consulted hematology clinic and a diagnosis of Multiple myeloma was made.
We considered that physicians should be conscious of this subject, especially in skin lesions with fever because this may
be a first sign of an underlying malignancy.
Keywords: Broad-spectrum antibiotics, cellulitis, multiple myeloma, paraneoplastic syndrome, splenomegaly, sweet syndrome.
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