An Engrossing History of Azidothymidine

Author(s): Vivek K. Sharma, Raman K. Sharma, Pramod K. Singh, Sunil K. Singh.

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)
(Formerly Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents)

Volume 15 , Issue 2 , 2015

Graphical Abstract:


Azidothymidine (AZT) was the first breakthrough drug developed for the treatment of acquired immunodeficiency syndrome (AIDS). It took AZT only 25 months from the first successful laboratory activity against human immunodeficiency virus (HIV) to its approval by the FDA. Similar interesting facts and disputes have persistently been associated with AZT starting from its very first synthesis to the development and approval as drug. This review briefly collates the exciting history of AZT and, as the different stages involved in the discovery and the development of this drug molecule gets recapitulated here, could well serve as a mnemonic for the area of drug discovery and development in general.

Keywords: Azidothymidine, nucleoside reverse-transcriptase inhibitor, antiretroviral drug, human immunodeficiency virus, acquired immunodeficiency syndrome.

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Article Details

Year: 2015
Page: [168 - 175]
Pages: 8
DOI: 10.2174/1871522215666150910205246
Price: $58

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