Preclinical studies have shown that phosphodiesterase inhibitors (PDE-Is) represent a potential
pharmacological strategy for the treatment of brain ischemia sequelea. PDE-Is 3, 4 and 5 have been tested in several brain
ischemia models. All the three PDE-Is after acute or chronic treatment decreased the degree of neurodegeneration and
most of them improved functional recovery after brain injury by specific cellular and molecular mechanisms mainly
involving an anti-inflammatory and/or neuroprotection action. In contrast to the large number of investigations using
PDE-Is in experimental brain ischemia research, the number of clinical studies is still limited. The purpose of this review
is to summarize the data currently available on the effects of PDE-Is in experimental models of cerebral ischemia.
Keywords: Animal models, brain ischemia, stroke, phosphodiesterase inhibitors.
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