Nitric oxide is a gaseous neuromodulator that displays a core role in several neuronal processes. Beyond
regulating the release of neurotransmitters, nitric oxide also plays a role in cell differentiation and maturation in the
central nervous system. Although the mode of action of nitric oxide is not fully understood, it involves the activation of
soluble guanylate cyclase as well as the nitration and S-nitrosylation of specific amino acid residues in other proteins.
Brain-derived neurotrophic factor is a member of neurotrophic factor family and, acting through its receptor tropomyosinrelated
kinase B, increases the production of nitric oxide, modulates neuronal differentiation and survival, and plays a
crucial role in synaptic plasticity, such as long-term potentiation. Furthermore, nitric oxide is an important regulator of the
production of these factors. The aim of the present review is to present a condensed view of the evidence related to the
interaction between nitric oxide and brain-derived neurotrophic factor. Additionally, we conducted bioinformatics analysis
based on the amino acid sequences of brain-derived neurotrophic factor and tropomyosin-related kinase receptors, and
proposed that nitric oxide might nitrate/S-nitrosylate these proteins. Thus, we suggest a putative direct mode of action
between these molecules to be further explored.
Keywords: Nitric oxide, brain-derived neurotrophic factor, tropomyosin-related kinase receptors, nitration, S-nitrosylation,
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