Alzheimer’s disease (AD) is a neurodegenerative disorder that is described by multiple factors
linked with the progression of the disease. The currently approved drugs in the market are not capable
of curing AD; instead, they merely provide symptomatic relief. Development of multi-target directed
ligands (MTDLs) is an emerging strategy for improving the quality of the treatment against complex
diseases like AD. Polypharmacology is a branch of pharmaceutical sciences that deals with the
MTDL development. In this mini-review, we have summarized and discussed different strategies that
are reported in the literature to design MTDLs for AD. Further, we have discussed the role of different
in silico techniques and online resources in computer-aided drug discovery (CADD), for designing or
identifying MTDLs against AD.
Keywords: Alzheimer's disease, CADD, polypharmacology, multi-target directed ligands.
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