Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

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CADD Modeling of Multi-Target Drugs Against Alzheimer's Disease

Author(s): Pravin Ambure, Kunal Roy.

Graphical Abstract:


Abstract:

Alzheimer’s disease (AD) is a neurodegenerative disorder that is described by multiple factors linked with the progression of the disease. The currently approved drugs in the market are not capable of curing AD; instead, they merely provide symptomatic relief. Development of multi-target directed ligands (MTDLs) is an emerging strategy for improving the quality of the treatment against complex diseases like AD. Polypharmacology is a branch of pharmaceutical sciences that deals with the MTDL development. In this mini-review, we have summarized and discussed different strategies that are reported in the literature to design MTDLs for AD. Further, we have discussed the role of different in silico techniques and online resources in computer-aided drug discovery (CADD), for designing or identifying MTDLs against AD.

Keywords: Alzheimer's disease, CADD, polypharmacology, multi-target directed ligands.

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Article Details

VOLUME: 18
ISSUE: 5
Year: 2017
Page: [522 - 533]
Pages: 12
DOI: 10.2174/1389450116666150907104855
Price: $58