Stem Cell-Derived Oligodendroglial Cells for Therapy in Neurological Diseases

Author(s): Juan A. García-León , Catherine M. Verfaillie .

Journal Name: Current Stem Cell Research & Therapy

Volume 11 , Issue 7 , 2016

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Abstract:

There are an important number of neurological diseases where not neurons but glia are the responsible cells for the degeneration of the nervous system. In the last years, determinant roles for oligodendrocytes (OLs) have been demonstrated not only in myelin generation and maintenance but also for metabolic support of neurons. Oligodendroglial defects lead to brain degeneration in several diseases, supporting the idea that not only endogenous regeneration but also administration of exogenous OL precursors will lead to overcome functional deficits. In this review, we discuss many diseases where OLs play a crucial role, and focus on the different sources and methods to obtain oligodendroglial cells that could be used in cell therapy for myelin-related and oligodendrocyte-deficient diseases.

Keywords: Amyotrophic lateral sclerosis, cell transplantation, leukodystrophies, multiple sclerosis, oligodendrocyte, stem cell therapy.

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Article Details

VOLUME: 11
ISSUE: 7
Year: 2016
Page: [569 - 577]
Pages: 9
DOI: 10.2174/1574888X10666150902095312
Price: $58

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