Nanoemulsion-based Parenteral Drug Delivery System of Carbamazepine: Preparation, Characterization, Stability Evaluation and Blood-Brain Pharmacokinetics

Author(s): Sim Ling Tan, Johnson Stanslas, Mahiran Basri, Abedi Karjiban R.A., Brian P. Kirby, Dahiru Sani, Hamidon Bin Basri.

Journal Name: Current Drug Delivery

Volume 12 , Issue 6 , 2015

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Graphical Abstract:


Carbamzepine (CBZ) was encapsulated in a parenteral oil-in-water nanoemulsion, in an attempt to improve its bioavailability. The particle size, polydispersity index and zeta potential were measured using dynamic light scattering. Other parameters such as pH, osmolality, viscosity, drug loading efficiency and entrapment efficiency were also recorded. Transmission electron microscopy revealed that emulsion droplets were almost spherical in shape and in the nano-range. The in vitro release profile was best characterized by Higuchi’s equation. The parenteral nanoemulsion of CBZ showed significantly higher AUC0→5, AUC0→∞, AUMC0→5, AUMC0→∞, Cmax and lower clearance than that of CBZ solution in plasma. Additionally, parenteral nanoemulsion of CBZ showed significantly higher AUC0→∞, AUMC0→∞ and Cmaxthan that of CBZ solution in brain. The parenteral nanoemulsion of CBZ could therefore use as a carrier, worth exploring further for brain targeting.

Keywords: Blood-brain pharmacokinetics, Characterization, Oil-in-water nanoemulsion, stability evaluation, parenteral.

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Article Details

Year: 2015
Page: [795 - 804]
Pages: 10
DOI: 10.2174/1567201812666150901112544
Price: $65

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