Dosage Form Developments of Nanosuspension Drug Delivery System for Oral Administration Route

Author(s): Ang Chen, Ye Shi, Zhiqiang Yan, Hongxun Hao, Yong Zhang, Jian Zhong, Huiming Hou.

Journal Name: Current Pharmaceutical Design

Volume 21 , Issue 29 , 2015

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Abstract:

A large amount of new drug candidates are practically insoluble in aqueous solvents and are even simultaneously poorly soluble in organic solvents. Nanosuspension drug delivery system (DDS) was firstly developed in 1994 and has attracted more and more attention as a formation solution for the poorly soluble drugs. By nansizing the poorly soluble drugs, nanosuspensions have several outstanding advantages for drug delivery. Among many administration routes of drug delivery, oral administration is the most preferred route due to its advantages such as ease of ingestion, versatility to accommodate various types of drug candidates, low production cost, high safety, good patient compliance, and pain avoidance. Current marketed pharmaceutical nanosuspension DDS products are mostly for oral administration. This review is to systematically summarize the nanosuspension DDS dosage form developments of poorly soluble drugs for oral administration use.

Keywords: Administration route, dosage form, drug delivery system, nanosuspension, oral administration.

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Article Details

VOLUME: 21
ISSUE: 29
Year: 2015
Page: [4355 - 4365]
Pages: 11
DOI: 10.2174/1381612821666150901105026
Price: $58

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