Many new developed drug actives are poorly soluble, therefore the need to increase the solubility of
these actives arises. Nanosuspensions are fast and easy to produce, enhance the bioavailability of poorly soluble
drugs and feature many beneficial characteristics. However, nanocrystals in suspension form are physically metastable.
Furthermore, the application of nanocrystal suspensions has no retarding effects. To overcome long term stability
issues and open up a variety of options for controlled release, nanocrystals can be converted into solid dosage
forms by different methods with different outcomes and features. Transformation of nanosuspensions into solid
dosage forms opens up manifold options for the development of dosage forms with tailor-made drug release profiles.
This review focuses on nanocrystal properties, established and new production techniques, as well as state of
the art techniques for transformation of nanosuspensions into solid dosage forms. Nanocrystal technology is already today used in several
solid products and holds great potential for future uses.
Keywords: Bioavailability, nanotechnology, nanocrystals, nanodispersions, nanosuspensions, solid dosage forms.
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