Nanotechnology and nanomedicine provide a platform for advanced therapeutic strategies for dermal
and transdermal drug delivery. The focus of this review is on the current state-of-art in lipid-based nanotechnology
and nanomedicine for (trans)dermal drug therapy. Drug delivery nanosystems based on the (phospho)lipid constituents
are characterized and compared, with the emphasis on their ability to assure the controlled drug release to
the skin and skin appendages, drug targeting and safety. Different types of liposomes, biphasic vesicles, particulate
lipid-based nanosystems and micro- and nano-emulsions are discussed in more details. Extensive research in preclinical
studies has shown that numerous parameters including the composition, size, surface properties and their
combinations affect the deposition and/or penetration of carrier-associated drug into/through the skin, and consequently determine the
therapeutic effect. The superiority of the most promising nanopharmaceuticals has been confirmed in clinical studies. We have selected
several common skin disorders and provided overview over promises of nanodermatology in antimicrobial skin therapy, anti-acne treatment,
skin oncology, gene delivery and vaccines. We addressed the potential toxicity and irritation issues and provided an overview of
registered lipid-based products.
Keywords: Skin, drug delivery nanosystems, nanopharmaceuticals, nanotechnology, skin therapy.
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