Major depressive disorder is a serious mental disorder that profoundly affects an
individual's quality of life. Although the aetiologies underlying this disorder remain unclear, an
increasing attention has been focused on the influence imposed by psychological stress over
depression. Despite limited animal models of psychological stress, significant progress has been
made as to be explicated in this review to elucidate the physiopathology underlying depression and
to treat depressive symptoms. Therefore, we will review classical models along with new methods
that will enrich our knowledge of this disorder.
Keywords: Brain-derived neurotrophic factor, depression, glial cell-derived neurotrophic factor, hippocampus, nucleus
accumbens, prefrontal cortex, psychological stress, ventral tegmental area.
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