Molecularly imprinted polymers (MIPs) are synthetic materials with tailor-made binding sites for a variety
of chemical substances. However, the optimization of MIPs formulation is time-consuming and labourintensive
since the interactions presenting in the pre-polymerisation mixture are complicated. Therefore,
chemometrics, in which mathematical or statistical methods are used to analyze data, has been regarded as a useful
tool to the optimization of MIP preparation. This article gave a mini review of the current status of the synthetic
strategies in MIPs based on chemometric and computational methods in the past decade. The perspectives in the computation-based optimization
for MIP preparation were also discussed.
Keywords: Molecularly imprinted polymers, design and evaluation, chemometrics, molecular dynamics.
Rights & PermissionsPrintExport