Copper-Catalyzed One-Pot Multicomponent Reactions: Synthesis of 4-Arylsulfenyl Pyrazoles

Author(s): Daniela H. Oliveira , Diego Alves , Raquel G. Jacob , Maurício C. D. F. Xavier .

Journal Name: Current Organic Synthesis

Volume 12 , Issue 6 , 2015

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Graphical Abstract:


We describe here a simple protocol for the synthesis of 4-(arylsulfenyl)-1H-pyrazoles by copper-catalyzed cyclocondensation and direct C–H bond sulfenylation reactions. The products were obtained in good yields by the reaction of a range of 1,3-diketones, arylhydrazines and arylthiols, using catalytic amount of CuI. This One-Pot Multicomponent protocol is an efficient method to synthesize new compounds with potential application in biological studies and material sciences.

Keywords: Catalysis, copper, green chemistry, heterocycles, multicomponent, pyrazoles, sulfur.

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Article Details

Year: 2015
Page: [822 - 829]
Pages: 8
DOI: 10.2174/157017941206150828114009
Price: $58

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