Dementia is an acquired progressive cognitive dysfunction, affecting the content of consciousness
rather than the level of consciousness. Most dementia is senile dementia, accounting for the
majority of dementia. The most important and common form of senile dementia is refractory dementia,
which includes Alzheimer's disease (AD) and vascular dementia (VD). Due to the diversity and
uncertainty of the pathogenic mechanism of VD and AD, no significantly effective drug currently exists.
Berberine is a natural isoquinoline alkaloid extracted from Coptis chinensis that has a wide range
of pharmacological effects. studies in recent years have also found that berberine can additionally treat
senile dementia by affecting neurotransmitter, anti-oxidative stress, metabolism and other multi-target
pathways. Multi-target treatment of senile dementia by berberine is a potential avenue of study for senile dementia treatment.
Keywords: Berberine, Senile dementia, Vascular dementia, Alzheimer's disease, Multi-target.
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