In the last two decades, dendrimers have proven their capabilities in drug delivery, physical stabilization
of the drug, solubility enhancement of the poorly soluble drugs and gene delivery. Several key features of dendrimers
such as excellent control over molecular structure, nanoscopic size, availability of multiple functional groups at
the periphery and narrow polydispersity index distinguish them as a superior choice over available polymers. The
diversity of bio-actives loaded in dendrimers due to covalent and non-covalent interactions, such as hydrogen bonding and hydrophobic
interaction contribute to the physical forces for binding of bioactives. The key advantage of drug-loaded dendrimers is the delayed and
sustained-release of bioactives because of the encapsulation of the drug in the hydrophobic cavities of the dendrimer that acts as a sink to
retain the drug molecules for extended duration. Because of these features researchers are particularly excited about the potential application
of dendrimers as a versatile carrier for drug delivery. Collectively, this review focuses on detailed note on the delivery and improved
solubility of poorly soluble anti-cardiovascular bioactives, nitric oxide (NO) donor for anti-thrombosis, gene delivery and delivery of receptor
agonists for cardio-protective action of the receptors using dendrimers.
Keywords: Dendrimer, cardiovascular disease, nitric oxide donor, thrombosis, adenosine receptors.
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