An Endogenous Tachykinergic NK2/NK3 Receptor Cascade System Controlling the Release of Serotonin from Colonic Mucosa

Author(s): Shu-ichi Kojima, Atsushi Tohei, Masashi Ikeda, Naohiko Anzai.

Journal Name: Current Neuropharmacology

Volume 13 , Issue 6 , 2015

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Graphical Abstract:


5-Hydroxytryptamine (5-HT) released from colonic mucosal enterochromaffin (EC) cells is a major signaling molecule, which participates in the pathophysiological regulation of colonic functions in gut disorder including irritable bowel syndrome (IBS), but the endogenous modulator system for the 5-HT release is not yet well elucidated. Our in vitro studies in guinea-pig colon have indicated that the cascade pathway of neuronal tachykinergic NK3 receptors and NK2 receptors on peptide YY (PYY)-containing endocrine L cells represents an endogenous modulator system for 5-HT release from EC cells and that melatonin, endogenous tachykinins and PYY play important roles in modulation of the release of 5-HT from EC cells via the endogenous NK2/NK3 receptor cascade system. This review aims at examining the potential role of the endogenous tachykinergic NK2/NK3 receptor cascade system controlling the release of 5-HT from EC cells, with special attention being paid to the pathophysiology of gut disorders including IBS.

Keywords: Colon, enterochromaffin cells, 5-HT (5-hydroxytryptamine, serotonin) release, melatonin, peptide YY, tachykinins, NK2 and NK3 receptors, Y1 receptors.

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Article Details

Year: 2015
Page: [830 - 835]
Pages: 6
DOI: 10.2174/1570159X13666150825220524
Price: $65

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